Teodoro Bottiglieri Selected Research

S-Adenosylmethionine (Ademetionine)

12/2017	Confirmation that MAT1A p.Ala259Val mutation causes autosomal dominant hypermethioninemia.
6/2017	S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research.
11/2016	Chronic Kidney Disease Induces Inflammatory CD40+ Monocyte Differentiation via Homocysteine Elevation and DNA Hypomethylation.
9/2015	A Phase II Randomized, Controlled Trial of S-Adenosylmethionine in Reducing Serum α-Fetoprotein in Patients with Hepatitis C Cirrhosis and Elevated AFP.
10/2013	Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma.
1/2013	Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia.
8/2009	S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model.
7/2005	Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.
12/2004	S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine.
1/2004	Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis.

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Teodoro Bottiglieri Research Topics

Disease

21	Hyperhomocysteinemia 01/2022 - 08/2002
10	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 03/2007
9	Major Depressive Disorder (Major Depressive Disorders) 06/2017 - 08/2004
8	Dementia (Dementias) 01/2022 - 06/2004
7	Body Weight (Weight, Body) 04/2021 - 09/2002
6	Parkinson Disease (Parkinson's Disease) 01/2022 - 06/2004
6	Inflammation (Inflammations) 01/2022 - 03/2006
6	succinic semialdehyde dehydrogenase deficiency 11/2020 - 01/2003
5	Cardiovascular Diseases (Cardiovascular Disease) 06/2017 - 11/2004
4	Weight Gain 04/2021 - 01/2014
4	Homocystinuria 01/2021 - 04/2005
4	Cognitive Dysfunction 01/2020 - 06/2008
4	Coronary Artery Disease (Coronary Atherosclerosis) 10/2018 - 12/2016
4	Sepsis (Septicemia) 01/2018 - 07/2003
4	Neoplasms (Cancer) 10/2017 - 08/2009
4	Schizophrenia (Dementia Praecox) 06/2017 - 09/2004
4	Neuroblastoma 11/2015 - 05/2006
3	Chronic Renal Insufficiency 07/2022 - 11/2016
3	Disease Progression 01/2022 - 03/2006
3	Methylenetetrahydrofolate reductase deficiency 01/2021 - 01/2014
3	Insulin Resistance 12/2020 - 11/2010
3	Ischemic Stroke 01/2020 - 01/2017
3	Vascular Diseases (Vascular Disease) 01/2018 - 04/2004
3	Thrombosis (Thrombus) 01/2018 - 10/2006
3	Fibrosis (Cirrhosis) 06/2017 - 01/2004
3	Phenylketonurias (Phenylketonuria) 01/2017 - 09/2014
3	Hepatocellular Carcinoma (Hepatoma) 09/2015 - 08/2009
3	Maple Syrup Urine Disease 05/2014 - 10/2009
3	Epilepsy (Aura) 10/2012 - 01/2003
2	Congenital Abnormalities (Deformity) 06/2022 - 01/2018
2	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 10/2017
2	Obesity 01/2021 - 01/2016
2	Gliosis 11/2020 - 01/2018
2	Multiple Sclerosis 01/2020 - 11/2015
2	Non-alcoholic Fatty Liver Disease 01/2019 - 11/2010
2	Pregnancy Complications 01/2018 - 01/2007
2	Fabry Disease (Fabry's Disease) 01/2018 - 01/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 07/2012
2	Hypermethioninemia 12/2017 - 09/2015
2	Type 2 Diabetes Mellitus (MODY) 01/2016 - 02/2013
2	Microcephaly 09/2015 - 10/2012
2	Carotid Artery Thrombosis 01/2014 - 10/2006

Drug/Important Bio-Agent (IBA)

30	Folic Acid (Vitamin M)FDA LinkGeneric 06/2022 - 08/2002
30	HomocysteineIBA 01/2022 - 08/2002
15	Methionine (L-Methionine)FDA Link 01/2022 - 01/2004
11	S-Adenosylmethionine (Ademetionine)IBA 12/2017 - 01/2003
9	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2020 - 07/2003
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2007
8	Choline (Choline Chloride)IBA 01/2022 - 01/2003
7	CarbonIBA 01/2022 - 10/2013
7	Betaine (C.B.B.)FDA Link 01/2021 - 11/2010
6	Biomarkers (Surrogate Marker)IBA 07/2022 - 06/2011
6	Cystathionine beta-Synthase (Serine Sulfhydrase)IBA 01/2020 - 09/2002
6	Amino Acids FDA Link 01/2019 - 10/2012
5	CystathionineIBA 01/2022 - 01/2013
5	5-methyltetrahydrofolateIBA 08/2014 - 06/2012
4	Levodopa (L Dopa)FDA LinkGeneric 01/2022 - 06/2004
4	AcidsIBA 04/2021 - 12/2007
4	gamma-Aminobutyric Acid (GABA)IBA 01/2020 - 01/2003
4	Neurotransmitter Agents (Neurotransmitter)IBA 01/2018 - 10/2012
4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 03/2007
4	S-AdenosylhomocysteineIBA 11/2016 - 07/2005
4	DNA (Deoxyribonucleic Acid)IBA 11/2016 - 08/2013
3	LipidsIBA 07/2022 - 01/2016
3	Apolipoproteins E (ApoE)IBA 01/2022 - 01/2007
3	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 01/2021 - 04/2004
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/2018 - 01/2017
3	EnzymesIBA 10/2017 - 02/2010
3	Superoxides (Superoxide)IBA 01/2017 - 08/2004
3	Nitric Oxide Synthase (NO Synthase)IBA 01/2017 - 08/2008
3	Insulin (Novolin)FDA Link 01/2016 - 11/2004
3	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 12/2012 - 12/2004
3	C-Reactive ProteinIBA 03/2010 - 11/2004
3	Fluoxetine (Prozac)FDA LinkGeneric 12/2005 - 08/2004
2	Cysteine (L-Cysteine)FDA Link 01/2022 - 01/2004
2	ApolipoproteinsIBA 01/2022 - 12/2014
2	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 01/2022 - 08/2008
2	5,11-methenyltetrahydrohomofolateIBA 04/2021 - 12/2020
2	Hormones (Hormone)IBA 01/2021 - 12/2020
2	Glutamine (L-Glutamine)FDA Link 11/2020 - 01/2019
2	Aminobutyrates (Aminobutyric Acid)IBA 01/2020 - 01/2019
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2020 - 01/2007
2	transcobalamin receptorIBA 01/2019 - 06/2013
2	Pharmaceutical PreparationsIBA 11/2018 - 01/2003
2	11-dehydro-thromboxane B2IBA 10/2018 - 01/2017
2	Vitamin B Complex (B Vitamins)IBA 01/2018 - 10/2008
2	GalactosidasesIBA 01/2018 - 01/2017
2	purineIBA 01/2018 - 05/2007
2	Oxygen (Dioxygen)IBA 10/2017 - 01/2007
2	Antidepressive Agents (Antidepressants)IBA 06/2017 - 12/2004
2	Thromboxane B2IBA 06/2017 - 12/2016
2	AntioxidantsIBA 01/2017 - 03/2006
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 11/2010
2	Branched-Chain Amino AcidsIBA 05/2014 - 06/2013
2	Leucine (L-Leucine)FDA Link 05/2014 - 11/2008
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2014 - 03/2007
2	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 01/2014 - 03/2007

Therapy/Procedure

8	Therapeutics 09/2018 - 02/2013
2	Diet Therapy (Therapy, Diet) 01/2018 - 10/2010
2	Liver Transplantation 09/2015 - 06/2013